David Sinclair
Harvard Medical School Professor of Genetics and longevity researcher whose work examines the genetic and epigenetic biology of aging; author of Lifespan and co-founder of biotechnology companies focused on age-related disease.
Partial Reprogramming Aims to Reverse Aging Without Erasing Cell Identity
Harvard geneticist David Sinclair argues that aging is partly a loss of cellular information that could be restored through partial epigenetic reprogramming. He says his lab’s first human trial, in the eye, is testing whether a three-gene approach can improve vision without erasing cell identity or triggering cancer; broader claims about whole-body rejuvenation remain based on animal and unpublished work. Until such therapies arrive, Sinclair’s prescription is conventional: protect health through weight, exercise, sleep, diet and risk-specific medical care.
Sinclair’s Two-Week Fast Relies on Supplements, Monitoring and Exercise
David Sinclair describes his two-week fasts as a monitored, supplement-supported personal practice, not a water-only regimen or general advice, while his broader case for eating less often rests chiefly on animal evidence. He says that after roughly three days without conventional meals, his hunger recedes and he feels clearer, less bloated and more energized.