Lon Harris
Host and commentator at This Week in Startups, where he covers startups, technology, media, and AI-related business trends; previously associated with LAUNCH and Mahalo.
GRU Space Plans Lunar-Regolith Bricks as the First Step Toward a Moon Hotel
On This Week in Startups, GRU Space founder Skyler Chan argues that a Moon hotel is the first commercial wedge for a larger off-Earth manufacturing business: using lunar regolith to make construction materials rather than shipping them from Earth. Chan lays out a plan to prove the technology by making a brick on the Moon, then scale toward robotic habitats, NASA construction work, space tourism and eventual claims on lunar resources. The same episode turns to Anthropic’s forced shutdown of Fable 5 and Mythos 5, which Jason Calacanis and Lon Harris frame as a warning that frontier capabilities can be cut off before law, politics and operating norms have settled.
GRU Space’s Moon Hotel Depends on Turning Lunar Dirt Into Infrastructure
Skyler Chan of GRU Space argues that the company’s proposed lunar hotel is less a tourism stunt than a test case for building infrastructure from the moon itself. In an interview with Jason Calacanis and Lon Harris, Chan said GRU’s core bet is that concentrated sunlight can melt lunar regolith into durable building material, reducing the need to haul construction supplies from Earth; the episode also used a contested rumor about Anthropic to examine how closely frontier AI labs are becoming tied to U.S. national-security institutions.
SpaceX’s IPO Forces Public Markets to Price a Venture-Scale Future
Jason Calacanis used SpaceX’s reported IPO to argue that public markets will misread the company if they treat it only as a near-term earnings story. On This Week in Startups, he framed SpaceX as part operating business and part venture bet: Starlink and launch can be measured today, while direct-to-phone service, orbital data centers, Moon bases and Mars remain longer-horizon wagers on Elon Musk’s execution. The episode then turned to Polsia founder Ben Cera, whose AI-run fundraising stunt was presented as a case study in attention that demonstrates the product rather than merely promoting it.
Sanders’ 50% AI Stock Plan Turns Training Data Into a Political Fight
Jason Calacanis argued that Anthropic’s call for an AI slowdown and Bernie Sanders’ proposal for public ownership of major AI companies show AI politics moving toward jobs, ownership and redistribution. He dismissed Sanders’ 50% stock-tax plan as unworkable but said its premise could resonate with voters who believe AI companies built enormous value from public and creative inputs while threatening employment. Yoland Yan’s ComfyUI demo supplied the production-layer version of the same control question, presenting generative AI as a workflow where exposed parameters and reproducibility matter more than prompt-box convenience.
Frontier Hardware Startups Face Infrastructure Constraints Beyond the Demo
Cortical Labs and Pyka show how frontier hardware companies move from demonstration to deployable infrastructure. On This Week in Startups, Cortical founder Hon Weng Chong presents the CL1 as a programmable biological computer that packages lab-grown neurons, silicon hardware, life support and cloud tools, and says unpublished work shows neurons can be 5,000 times more sample-efficient than GPU-based reinforcement learning systems. Pyka chief executive Michael Norcia argues that autonomous aircraft face a different bottleneck: not whether they can fly, but whether regulation, uptime, maintenance and field deployment allow them to improve in real use.
Seed Founders Need 150 Qualified Investor Targets in 2026
Jason Calacanis uses a This Week in Startups “Ask Jason” segment to argue that raising a seed round in 2026 requires founders to treat fundraising as a qualified sales process, not a test of investor warmth. His benchmark is a large, researched funnel — about 150 seed funds contacted, 50 first meetings, 15 to 20 second meetings, and two term sheets — backed by more product and customer proof than early-stage companies once needed. He also argues that AI startups must build around workflow and distribution rather than generic model output, while hardware has become harder but more investable when it creates real lock-in.
Software-Defined Factories Are Moving From Hypercars to Cruise Missiles
Lukas Czinger, chief executive of Divergent Technologies, argues on This Week in Startups that U.S. defense manufacturing can move faster and at lower cost if factories are treated as software-defined infrastructure rather than product-specific plants. The article also follows Brandon Goode and Mark Horowitz’s case for Outro Health: that antidepressant prescribing has scaled without an equally developed system for helping patients stop safely. Across the defense, healthcare and AI segments, the source frames the central problem as incentives — what existing systems pay companies to build, maintain or automate, and what they leave underbuilt.