In the 17th century, Dutch scientist Antonie van Leeuwenhoek, a draper by trade, crafted his own powerful single-lens microscopes. With them, he was the first human to witness a hidden world of 'animalcules'—bacteria, protozoa, and blood cells. This is the story of his relentless curiosity and meticulous observation, which opened the door to the entire field of microbiology.
In the Dutch city of Delft, a place of luminous canals and meticulous painters, Antonie van Leeuwenhoek was a man of cloth. Born in 1632, his world was one of textures and threads, of selling linen, yarn, and ribbon from the shop he opened in 1654. He was a draper, a practical man in a prosperous city during the Dutch Golden Age. His concern was the quality of his goods. To inspect the weave, to count the threads per inch with an expert eye, drapers used magnifying glasses. It was this simple, commercial tool that first opened a door for him. He was not a scholar. He had no university education, knew no Latin or foreign languages, the lingua franca of European intellectuals. He was an apprentice in Amsterdam for six years, learning the cloth trade, before returning to his hometown to build a life. He married a draper’s daughter, Barbara de Mey, and secured a comfortable position as chamberlain for the Delft sheriffs, a respectable municipal job he would hold for nearly four decades. This provided security, an income that allowed a man to pursue a hobby. And Leeuwenhoek’s hobby became an obsession. The small lenses of the drapery trade were not enough. He wanted to see more, to see better. He began to grind his own. There, in his shop, surrounded by bolts of fabric, he taught himself the delicate art. He would take a small rod of soda-lime glass, heat its middle in a hot flame until it glowed, then pull it apart, creating two long, thin whiskers of glass. By reinserting the tip of a whisker into the flame, a tiny, perfect sphere of glass would form. This was his lens. He learned to grind and polish these minuscule beads with astonishing precision, creating lenses of a power and clarity no one had ever achieved. He mounted them between two small, flat plates of copper or silver, riveted together. A pin held the specimen on the other side, and a set of screws allowed him to adjust its position and focus. They were not like the compound microscopes being developed elsewhere, instruments with multiple lenses in a tube. Leeuwenhoek's devices were smaller, barely a couple of inches long, and required holding the lens almost directly against the eye. But they were powerful. While the finest compound microscopes of the day might magnify an object 50 times, Leeuwenhoek’s simple, single lens could magnify it by over 200, some perhaps even 500 times. He guarded his methods jealously, admitting there were aspects of their construction "which I only keep for myself."
It began with water. In 1674, he took a look at the murky water from a nearby lake. He applied a droplet to the pin of his tiny viewing machine. What he saw was not just water. It was a swarm. It was a bustling, thriving world of creatures "very prettily a-moving." He saw them shoot through the water "like a pike does through the water." He saw others that "oft-times spun round like a top." He called them *dierkens* or *diertjes* in his native Dutch—little animals. When translated for the learned men of London, they became "animalcules." This was a universe no human had ever reported seeing. At the time, the prevailing wisdom held that such small creatures—maggots, fleas—could arise spontaneously from dust or decay. But Leeuwenhoek saw life, intricate and active. He started writing letters, over 300 of them over the next 50 years, to the Royal Society in London, the most prestigious scientific body in the world. He wrote not in Latin, but in plain Dutch, describing his observations with the meticulous detail of a shopkeeper taking inventory. He looked at everything. He described the sting of a bee, the structure of a human louse. He was the first to see the single-celled organisms we now call protozoa. He observed the flow of blood cells through the capillaries in the tail of an eel. He discovered bacteria in 1676 and spermatozoa a year later, correctly concluding that fertilization occurred when these tiny animalcules entered an egg. The gentlemen of the Royal Society were skeptical. This Dutch draper with no formal training was describing a world that seemed fantastical. Widespread doubt met his letters. But Leeuwenhoek was relentless. To prove his claims about the creatures in his own mouth, he had a notary co-sign his observations. He sent detailed drawings. He was a scientist by nature, if not by training, a man driven by an insatiable curiosity.
His most famous observation came not from a pond, but from his own body. On September 17, 1683, he sent a letter to London detailing what he found in the white matter scraped from between his own teeth. He mixed the plaque with clean rainwater and put it under his lens. There, he saw "with great wonder... many very little living animalcules." He described their frantic, varied movements, a microscopic ballet of bacilli and spirochetes. It was the first documented observation of bacteria from the human body. He did not connect these creatures to disease; that leap would take another two centuries. For him, it was enough to see, to document, to be the first witness. His work slowly dismantled the idea of spontaneous generation for smaller animals, as he meticulously documented the life cycles of fleas, proving they bred "in the regular way of winged insects" and did not simply arise from sand or dust. For fifty years, he sat in his house in Delft, a prosperous draper and city official, and peered through his tiny lenses. He outlived two wives and four of his five children, with his surviving daughter Maria taking care of him in his old age. He never published a scientific book in the traditional sense, but his hundreds of letters, translated and published by the Royal Society, laid the very foundation of microbiology. The man of cloth had revealed a hidden texture to the world, a fabric of life woven on a scale so small it had remained invisible until a curious draper decided he needed a better look.